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ORGANSAVE
BioTeke
'ORGANSAVE', is a disruptive product based on cutting-edge glyco and antiodant science.
It used for the clinical transplantation transportation of solid organs such as heart, liver, kidney, lung and cornea, which greatly expands the geographical radius of organ allocation.
Life's Sorrow
More than 28% of donated organs worldwide are discarded each year because they lose their activity during transport, meaning countless lives that could have been saved arelost in the waiting room.
Time Constraints
The "golden hour"for heart transplants is only four hours, and no more than 24 hours for kidneys, with geography being one of the biggest barriers to transplantation.
Technical Bottleneck
Traditional preservation fluid contains high potassium and high osmotic pressure components, which are easy to cause vascular endothelial damage; and can not effectively combat oxidative stress, resulting in low cell survival rate.
Lack of Scene
In extreme conditions such as battlefield rescue, major accidents and remote areas, there is a lack of portable, efficient and long-term organ preservation solutions.
Production Demand
The market urgently needs a new preservation solution that can significantly prolong the survival time of organs, has clear composition, easy access to raw materials, controllable cost and convenient production.
Core Ingredients
Trehalose, GSH, HES, allopurinol, adenosine, hydrogen water, etc.
Instead of a simple mix-and-match design, ORGANSAVE is based on amulti-target, multi-level philosophy of organ protection.
"Physical protection"layer
Using trehalose+HES to maintain the physical and chemical integrity of cell morphology and structure, and resist the physical damage caused by low temperature.
"Chemical protection"layer
Through GSH+allopurinol+hydrogen-rich water, atriple antioxidant defense line is constructed to inhibit free radicals from the source, intercept them in the middle and eliminate them completely, so as to achieve "fullcoverage" protection against oxidative damage.
"Energy and metabolism"layer
Add adenosine to supplement energy, and use HEPES buffer to maintain the internal environment stability, so as to maximize the survival time of cells in the"dormant" state.
"Safety"principle
All ingredients are non-toxic and non-animal-derived, avoiding the risk of immune rejection and disease transmission, raw materials are easy to obtained, and the supply chain is safe and reliable.
| Diamension of Characteristics | Traditional Preservation Fluid | ORGANSAVE Preservation Fluid |
| Core technologies | Classic recipe 40 years ago | Sugar biology + hydrogen molecular medicine modern frontier technology |
| Protection mechanism | Static cold preservation, passive protection | Active multi-target protection(physical, chemical and energy) |
| Oxidation resistance | Single or double, with side effects | Triple synergistic antioxidant (GSH + allopurinol + H2), selective, no side effects |
| Cell viability | There are bottlenecks and time constraints | Significantly improved (Experimental data: corneal endothelial cell suivival rate ＞99%) |
| Storage duration | Heart ＜4H, Kidney ＜24H | The target was extended to 72 hours |
| Raw materials and safety | Contains high potassium and lactate, which are risky for damage | No animal source, low potassium, physiological pH |
| Cost and accessibility | Expensive | The cost is reduced by 60% |
| Application scenarios | Primarily clinical | Clinical/Emergency/Scientific research/Space |
'ORGANSAVE', is a disruptive product based on cutting-edge glyco and antiodant science.
It used for the clinical transplantation transportation of solid organs such as heart, liver, kidney, lung and cornea, which greatly expands the geographical radius of organ allocation.
Life's Sorrow
More than 28% of donated organs worldwide are discarded each year because they lose their activity during transport, meaning countless lives that could have been saved arelost in the waiting room.
Time Constraints
The "golden hour"for heart transplants is only four hours, and no more than 24 hours for kidneys, with geography being one of the biggest barriers to transplantation.
Technical Bottleneck
Traditional preservation fluid contains high potassium and high osmotic pressure components, which are easy to cause vascular endothelial damage; and can not effectively combat oxidative stress, resulting in low cell survival rate.
Lack of Scene
In extreme conditions such as battlefield rescue, major accidents and remote areas, there is a lack of portable, efficient and long-term organ preservation solutions.
Production Demand
The market urgently needs a new preservation solution that can significantly prolong the survival time of organs, has clear composition, easy access to raw materials, controllable cost and convenient production.
Core Ingredients
Trehalose, GSH, HES, allopurinol, adenosine, hydrogen water, etc.
Instead of a simple mix-and-match design, ORGANSAVE is based on amulti-target, multi-level philosophy of organ protection.
"Physical protection"layer
Using trehalose+HES to maintain the physical and chemical integrity of cell morphology and structure, and resist the physical damage caused by low temperature.
"Chemical protection"layer
Through GSH+allopurinol+hydrogen-rich water, atriple antioxidant defense line is constructed to inhibit free radicals from the source, intercept them in the middle and eliminate them completely, so as to achieve "fullcoverage" protection against oxidative damage.
"Energy and metabolism"layer
Add adenosine to supplement energy, and use HEPES buffer to maintain the internal environment stability, so as to maximize the survival time of cells in the"dormant" state.
"Safety"principle
All ingredients are non-toxic and non-animal-derived, avoiding the risk of immune rejection and disease transmission, raw materials are easy to obtained, and the supply chain is safe and reliable.
| Diamension of Characteristics | Traditional Preservation Fluid | ORGANSAVE Preservation Fluid |
| Core technologies | Classic recipe 40 years ago | Sugar biology + hydrogen molecular medicine modern frontier technology |
| Protection mechanism | Static cold preservation, passive protection | Active multi-target protection(physical, chemical and energy) |
| Oxidation resistance | Single or double, with side effects | Triple synergistic antioxidant (GSH + allopurinol + H2), selective, no side effects |
| Cell viability | There are bottlenecks and time constraints | Significantly improved (Experimental data: corneal endothelial cell suivival rate ＞99%) |
| Storage duration | Heart ＜4H, Kidney ＜24H | The target was extended to 72 hours |
| Raw materials and safety | Contains high potassium and lactate, which are risky for damage | No animal source, low potassium, physiological pH |
| Cost and accessibility | Expensive | The cost is reduced by 60% |
| Application scenarios | Primarily clinical | Clinical/Emergency/Scientific research/Space |
