Cervical cancer remains one of the most preventable malignancies through evidence-based screening programs. With advances in molecular diagnostics, screening strategies have evolved from cytology-based approaches to HPV testing–centered models.
According to the American Cancer Society (ACS) Cervical Cancer Screening Guidelines, HPV testing is the preferred primary screening method for average-risk individuals with a cervix. This article provides a professional interpretation of the latest guidelines, with a focus on HPV testing, screening intervals, and clinical implementation.