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ICA2403
Bioteke
B. Detection Principle
Alpha fetoprotein (AFP) is a glycoprotein belonging to the albumin family, mainly synthesized by fetal liver cells and yolk sac.
AFP has a high concentration in fetal blood circulation, which decreases after birth. From 2 to 3 months after birth, AFP is basically replaced by albumin and is difficult to detect in the blood, so its content is extremely low in adult blood.
AFP has many important physiological functions, such as transport function, bidirectional regulatory function as a growth regulatory factor, immune suppression, and T lymphocyte induced apoptosis. AFP is related to the occurrence and development of liver cancer and various tumors, and can exhibit high concentrations in various tumors.
This kit is an immunochromatographic kit that uses a double antibody sandwich method to detect AFP in human blood samples.
C. Clinical Significance
1. Detection of AFP content in adult blood: AFP content in 60%~70% patients with primary liver cancer increases, in addition, AFP content in patients with testicular cancer, ovarian tumor, malignant teratoma, pancreatic cancer, gastric cancer, intestinal cancer, lung cancer and other patients will also increase.
2. Detection of AFP levels in childhood blood: AFP levels increase in liver cancer, hepatoblastoma, gonadal teratoblastoma, hepatitis, and other conditions.
3. Patients with benign liver diseases such as acute and chronic hepatitis and cirrhosis also have varying degrees of elevated blood AFP levels, but most of them are below 1000ng/mL, which is related to the degree of liver cell necrosis and regeneration.
4. Generally, the increase in AFP content in benign liver disease is transient and usually lasts for 2-3 weeks. Malignant tumors, on the other hand, continue to rise. Therefore, dynamic observation of serum AFP levels can distinguish between benign and malignant liver diseases, as well as early diagnosis of liver cancer.
5. Physiologically, AFP is secreted by newborn and immature liver cells. The fetal liver cells are not fully developed (differentiated) and secrete a large amount of alpha fetoprotein, which can enter the maternal blood through umbilical cord blood. Therefore, pregnant women will test positive for alpha fetoprotein during pregnancy. In clinical practice, AFP is mainly used as a blood marker for primary liver cancer, for the diagnosis and efficacy monitoring of primary liver cancer.
D. Package Components
(1 Test/Kit)
Specimen: Serum/Plasma/Whole Blood
Please refer to the User Manual for the test process.
Note:
1. Before testing, please carefully read these usage instructions. Only by following all instructions correctly can testing be reliable.
2. Ensure that the sample loading is appropriate, as results of excessive or insufficient sample loading may be unreliable.
3. The test results of this reagent kit are for clinical reference only. Doctors should make a final diagnosis by combining various test results and clinical symptoms.
4. The result may be interfered by HAAA (human anti animal antibody), heterophilic antibody, self analyte antibody, rheumatoid factor, and other proteins such as hormone binding proteins in the blood of patient.
E. Storage Conditions and Shelf Life
1. Storage Condition: A dry and dark place at 2-30 ℃.
2. Shelf Life: 2 years and should not be frozen.
3. The reagent should be used as soon as possible within 1 hour after opening the aluminum foil bag.
When the ambient temperature is above 30 ℃ or the humidity is high, it is recommended to use the reagent as soon as possible.
F. Related Products
Tumor Marker NSE test
Tumor Marker HE4 test
Tumor Marker CA15-3 test
B. Detection Principle
Alpha fetoprotein (AFP) is a glycoprotein belonging to the albumin family, mainly synthesized by fetal liver cells and yolk sac.
AFP has a high concentration in fetal blood circulation, which decreases after birth. From 2 to 3 months after birth, AFP is basically replaced by albumin and is difficult to detect in the blood, so its content is extremely low in adult blood.
AFP has many important physiological functions, such as transport function, bidirectional regulatory function as a growth regulatory factor, immune suppression, and T lymphocyte induced apoptosis. AFP is related to the occurrence and development of liver cancer and various tumors, and can exhibit high concentrations in various tumors.
This kit is an immunochromatographic kit that uses a double antibody sandwich method to detect AFP in human blood samples.
C. Clinical Significance
1. Detection of AFP content in adult blood: AFP content in 60%~70% patients with primary liver cancer increases, in addition, AFP content in patients with testicular cancer, ovarian tumor, malignant teratoma, pancreatic cancer, gastric cancer, intestinal cancer, lung cancer and other patients will also increase.
2. Detection of AFP levels in childhood blood: AFP levels increase in liver cancer, hepatoblastoma, gonadal teratoblastoma, hepatitis, and other conditions.
3. Patients with benign liver diseases such as acute and chronic hepatitis and cirrhosis also have varying degrees of elevated blood AFP levels, but most of them are below 1000ng/mL, which is related to the degree of liver cell necrosis and regeneration.
4. Generally, the increase in AFP content in benign liver disease is transient and usually lasts for 2-3 weeks. Malignant tumors, on the other hand, continue to rise. Therefore, dynamic observation of serum AFP levels can distinguish between benign and malignant liver diseases, as well as early diagnosis of liver cancer.
5. Physiologically, AFP is secreted by newborn and immature liver cells. The fetal liver cells are not fully developed (differentiated) and secrete a large amount of alpha fetoprotein, which can enter the maternal blood through umbilical cord blood. Therefore, pregnant women will test positive for alpha fetoprotein during pregnancy. In clinical practice, AFP is mainly used as a blood marker for primary liver cancer, for the diagnosis and efficacy monitoring of primary liver cancer.
D. Package Components
(1 Test/Kit)
Specimen: Serum/Plasma/Whole Blood
Please refer to the User Manual for the test process.
Note:
1. Before testing, please carefully read these usage instructions. Only by following all instructions correctly can testing be reliable.
2. Ensure that the sample loading is appropriate, as results of excessive or insufficient sample loading may be unreliable.
3. The test results of this reagent kit are for clinical reference only. Doctors should make a final diagnosis by combining various test results and clinical symptoms.
4. The result may be interfered by HAAA (human anti animal antibody), heterophilic antibody, self analyte antibody, rheumatoid factor, and other proteins such as hormone binding proteins in the blood of patient.
E. Storage Conditions and Shelf Life
1. Storage Condition: A dry and dark place at 2-30 ℃.
2. Shelf Life: 2 years and should not be frozen.
3. The reagent should be used as soon as possible within 1 hour after opening the aluminum foil bag.
When the ambient temperature is above 30 ℃ or the humidity is high, it is recommended to use the reagent as soon as possible.
F. Related Products
Tumor Marker NSE test
Tumor Marker HE4 test
Tumor Marker CA15-3 test
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